Hexoskin for Neurological Disease Research and Biomarker Development

Hexoskin sensors are increasingly used in neurological research and clinical monitoring because they can continuously measure surrogates of central nervous system activity such as ECG-derived heart rate variability (HRV), breathing patterns (including rapid breathing and pauses), and motor activity.

This approach makes phenotype definition practical for a wide range of rare neurological diseases, and helps researchers define efficient trials with objective and fast endpoints to measure neurological improvement.

In Epilepsy, Hexoskin data have been used to study autonomic changes preceding seizures, helping improve seizure detection and prediction models through physiological markers like heart rate variability and breathing irregularities during sleep (papers available on Pubmed [1], [2], [3]).

In Rett syndrome, continuous monitoring provides insight into irregular breathing patterns, autonomic instability, and sleep disturbances, which are key clinical concerns. 

In Congenital Central Hypoventilation Syndrome (CCHS), Hexoskin sensors offer a safe, noninvasive way to track breathing effort, HRV, and noctural hypoventilation in real-world conditions.

For patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), wearable monitoring enables objective assessment of fatigue and autonomic dysfunction outside clinical settings.

Similarly, in GRIN disorders, which affect neuronal signaling and motor control, Hexoskin recordings help quantify the physiological impact of movement disorders and autonomic symptoms.

Overall, Hexoskin’s ability to collect high-resolution, multimodal physiological data over long periods supports a deeper understanding of neurological diseases as systemic disorders affecting both neural and autonomic regulation. This approach generalizes across neurology by enabling continuous, objective, and scalable monitoring of brain–body interactions, facilitating precision medicine and early intervention for a broad range of neurological conditions. 

Contact our team today to discuss how Hexoskin can support you in your neurological physiological monitoring projects.